PARAMEDIC-3 research study

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PARAMEDIC-3 is an opportunity for paramedics to participate in a research study for patients in out of hospital cardiac arrest.


PARAMEDIC-3 hosted by Warwick Clinical Trials Unit is a multi-centre, individually randomised, superiority trial of an intraosseous access first strategy for adult patients who sustain an out-of-hospital cardiac arrest. Patients will be randomised to either an intraosseous first strategy or an intravenous first strategy group using a randomisation envelope provided to paramedics once trial training is complete.


The primary objective of this trial is to evaluate the clinical effectiveness of intraosseous-first strategy in the treatment of out-of-hospital cardiac, measured by 30-day survival.

Inclusion criteria

    1. Out-of-hospital cardiac arrest currently receiving cardiopulmonary resuscitation
    2. Requirement for vascular access to administer cardiac arrest drugs

Exclusion criteria

    1. Children (known or appear to be <18 years)
    2. Known or apparent pregnancy
    3. Already have vascular access


Recruiting hospital sites include Royal Bournemouth, University Hospitals Plymouth and Royal Cornwall Hospital Truro. Further sites and all start dates to be confirmed.


Training is available on my ESR for participating areas. Training is optional and does not affect mandatory compliance. A voucher will be gifted following successful assessment.

To complete the application, please follow the QR code or contact for further information.